Farmington is a city in St. Francois County, Missouri, United States located 60 miles south of St. Louis, Missouri. The population was 13,924 at the 2000 census. It is the county seat of St. Francois County.

The Farmington Micropolitan Statistical Area embraces St. Francois County and Washington County.  Nearest city with pop. 50,000+: St. Louis, MO (59.8 miles , pop. 348,189).Nearest city with pop. 1,000,000+: Chicago, IL (338.1 miles , pop. 2,896,016).Nearest cities: Leadington, MO (5.8 miles ), Park Hills, MO (7.5 miles ), Desloge, MO (9.2 miles ), Leadwood, MO (12.9 miles ), Bonne Terre, MO (13.1 miles ), Bismarck,MO (14.0 miles ), Iron Mountain Lake, MO (15.2 miles ), Junction City, MO (17.4 miles ).